The Medipix technology is one of CERN’s most successful knowledge transfer cases. Each collaboration has triggered a significant number of commercial activities in widely differing application areas. Medical imaging, space dosimetry, education, and material analysis just to mention a few. Moreover, the industrial partners and license holders commercialising the Medipix technology range from established enterprises to start-up companies. Thus, the technology is contributing to value creation, not only in its application areas, but also through business creation.